Raking 4th as the NFL's All-Time Leading Rusher, Barry Sanders is considered one of the greatest, if not the best running backs the NFL has ever seen. Barry Sanders played most of his illustrious career on subpar teams with the Detroit Lions. Still, this dynamic runner holds many NFL records such as: Became only the third player to reach 2,000 yards in a single season, and 15 career touchdown runs of 50 yards or more, most in NFL history.